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Retrospective analysis focused on finding the most successful clubs in the education of young hockey talents in the 70s, 80s and 90s in the Czech Republic
RŮŽEK, Josef
The aim of this bachelor thesis was to find out the most successful clubs in development of young hockey players in seventies, eighties, and nineties in Czech Republic. In the analytical part we were interested in development of ice-hockey player and physiological conditions. We were also concerned with professional army sport. In synthetic part we mentioned all ice-hockey clubs, which played their part in developing top ice-hockey players. We also described five best ice-hockey clubs. We found out that in last 30 years there were 202 representational players, including 21 goalkeepers, 69 defenders and 112 attackers, on major tournaments. The most successful club was HC Dukla Jihlava, because of their program, which helped 54 players till they reach twenty years of age.
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Hormonal synchronization of fetal circadian clocks in suprachiasmatic nuclei
Kapsdorferová, Viktória ; Sumová, Alena (advisor) ; Sehadová, Hana (referee)
Rhythmic non-light maternal signals, such as various behavioral, neurohumoral or metabolic factors, may play a key role in synchronization of the fetal circadian clock. This diploma thesis focuses more closely on the possible role of leptin and dopamine in the hormonal synchronization of the fetal central clock resides in the suprachiasmatic nuclei of the hypothalamus. A transgenic mouse fetus, which has luciferase fused to the clock gene Period 2, was used as an experimental model. This allowed us to monitor the operation of the fetal central clock in real time by recording the bioluminescence of tissue explants. Exogenous administration of dopamine during the decline in bioluminescence at normalized circadian time 15 induces larger phase delays compared to vehicle. Leptin, on the other hand, can participate in the development of spontaneous rhythms by stabilizing the integrity of the circadian rhythm, manifested by slowing down the rhythm dampening. At the level of individual cellular oscillators, significant regional differences in amplitude and period were not observed using bioluminescence microscopy. However, a slight dispersion of cell phases was observed after administration of dopamine during decreasing bioluminescence. In the case of leptin, there was a prolongation of period of the cell...
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Consequences of perinatal insult on brain excitability in immature and adult rats
Fábera, Petr ; Mareš, Pavel (advisor) ; Pokorný, Jaroslav (referee) ; Ošlejšková, Hana (referee)
Perinatal insult may lead to a permanent impairment of brain function resulting in the development of epilepsy. Status epilepticus (SE) in immature rats leads to hippocampal hyperexcitability. The functional and morphological changes of the hippocampus are similar to those seen in human temporal lobe epilepsy. The excitability may be influenced by adenosine. Adenosine acts its anticonvulsant effect by activation of A1 receptors (A1R). The concentration of adenosine is regulated by adenosine kinase (ADK) present in two isoforms - ADK-L and -S. The main goal of the thesis is to elucidate the changes in A1R and ADK isoforms expression during intact brain development and after SE. A1R agonist 2-chloro-N6- cyclopentyladenosine (CCPA), as well as inhibition of ADK by 5-iodotubercidin (5-ITU), may bolster the anticonvulsant effect, but their action may correspond with the level of A1R and ADK. Hippocampal excitability in immature rats after LiCl-pilocarpine SE was studied by the model of hippocampal afterdischarges (ADs) and correlated with changes of A1R and ADK in the hippocampus. ADs demonstrated significantly decreased hippocampal excitability shortly after SE induction, whereas significant hyperexcitability accompanied by spontaneous seizures in older rats was shown. Increasing ADK-S expression...
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Possibilities of physiotherapy for patients with postdysplastic coxarthrosis
KRÁL, Tomáš
This bachelor thesis deals with the possibilities of influencing the health status of patient with conservatively treated posdysplastic coxarthrosis through physiotherapy, as well as maintaining patient´s highest possible quality of life. The theoretical part includes a description of the hip joint anatomy, including the description of surrounding muscles and their function, which take part in the hip kinesiology. More detailed kinesiology and biomechanics are defined in a special chapter. Another section of theoretical part deals with the topic of physiological development of the hip joint, as well as the description of the nature of dysplasia. Furthermore, this part deals with the topic of osteoarthritis, with focus on osteoarthritis of the hip joint, caused by dysplasia. This chapter is directly followed by description of physiotherapeutic solutions for this problem. As the conclusion of the theoretical part is the description of the operational solutions and their indications. The aim of the theoretical part was to summarize the information about the kinesiology of the hip joint and the possible consequences of disrupting its physiology into a comprehensive set. Furthermore, the aim was to provide the summary of information about physiotherapeutic approaches and other solutions to this problem. This can be used as a more detailed informational material for patients, or as an ancillary material for physiotherapists. The practical part was realized with the use of qualitative research, from which were the obtained data processed in the form of individual case reports, which include both inputand output- kinesiological examinations, course of those therapies and long-term and short-term therapeutic plan. Three patients diagnosed with postdysplastic coxarthrosis participated in the study. In all tested probands, there was a certain kind of influence on functional pathological changes. Post-exercise and resting pain were alleviated. The therapy also brought positive changes in hip stabilization and increased the HSSP activation. Overall, there was an improvement in soft tissue adhesion and a reduction in pain produced by tissue reflex changes. Two patients also had a slight improvement in gait stereotype and overall posture. One of the results was also the stretching and light strengthening of certain muscles and muscle groups.
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Changes of movement abilities during ontogenesis in youth sports' children.
Sádecká, Kristýna ; Malá, Lucia (advisor) ; Šteffl, Michal (referee)
Title: Changes in motor skills during ontogenesis in young children of schoolage. Objectives: The aim of the work was to identify changes in movement abilities during ontogeny in sports children of younger school age. Methods: This work is processed by the method of data analysis, which we drew from the available literature, documents and professional articles. We also used the method of comparison, which was used to compare the data with the data we obtained from the elementary school Benešovo nám. and further compared them using graphs and tables. The research from the obtained data is carried out from the first stage of primary school, specifically from the 2nd, 3rd and 5th grade, and consists of tests for long jump, sprint for 60 m and throwing a ball. Here we used basic statistical characteristics such as arithmetic mean, standard deviation. Results: As a result of the work, the first hypothesis of non-linear change in the 60m run test between 3-5 was not confirmed. class. For the second hypothesis, smaller gender differences in the development of speed skills than in strength skills were confirmed. By evaluating for practice, we can say that children's motor skills change and it is important to focus on them individually. The development of individual abilities is very important and the...
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Rhythmic function of placenta and the impact of disruption in maternal-placental-fetal axis
Světlíková, Nela ; Sumová, Alena (advisor) ; Pačesová, Dominika (referee)
In mammals, the circadian rhythms result of a complex endogenous system consisting of hierarchically organized oscillators. The system enables the synchronization of the organism's internal processes with the external environment. It consists of the main component, the central clock, located in the suprachiasmatic nuclei in the hypothalamus, and peripheral clocks in other cells, tissues and organs. The placenta is a temporary, specialized mammalian organ that is part of the mother-placenta-fetus axis and exhibits rhythmicity in its functions. The aim of this thesis is to summarize the rhythmic functions of the placenta, such as immunity, protection, and production of hormones and other mediators that play an important role in fetal development and pregnancy. In addition, the thesis also describes rhythmic changes, that occur during pregnancy in the mother-placenta-fetus axis and how these rhythms influence each other. Keywords Placenta, circadian clock, ontogenesis, fetus, maternal synchronization, hormones, enzymes, immunity
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Effect of maternal obesity on postnatal development of circadian clocks
Sejrková, Veronika ; Sumová, Alena (advisor) ; Spišská, Veronika (referee)
This thesis focuses on the synchronizing effect of obesity in mothers on ontogenesis of the circadian system in their offspring during gestation and postnatal life. Additionally, the work summarizes its impact on health of offspring in adulthood. During postnatal life, the central clock oscillator (SCN) is synchronized with external conditions through alternating period of light and darkness, but during prenatal ontogenesis of the main oscillator and peripheral oscillators, the SCN is synchronized with maternal signals, both behavioral, metabolic and hormonal. In the event of disruption of the maternal circadian and metabolic systems due to obesity, the circadian clocks of the offspring are incorrectly synchronized during gestation and breastfeeding, which may have a long-term effect on their health later during postnatal life. Maternal obesity is considered the main trigger for obesity occurring later.
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Development of callosal interhemispheric connection in laboratory rat
Matternová, Lucie ; Mareš, Pavel (advisor) ; Žiak, Jakub (referee)
Corpus callosum is the main commissure linking cortex of the right and left brain hemisphere. For the first time, the callosal axons are observed during E18, when they cross the midline. In PND 5, most axons reach the contralateral cortex, and at the end of the second postnatal week, the callosal projection neurons and axon terminals are located similarly to the adult animal. The interhemispheric response was first observed in the rat in PND 4 but myelination in PND 12, suggesting that the transcallosal response is not dependent on myelinization of callosal fibers. As the rat age increases, the wave duration of the TCR, latency peak and threshold decreases. As opposed to that, amplitude of the positive and negative wave increases with age. TCR may be affected by acute drug application or chronic exposure to various effects, such as hormones.
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The mitochondrial genome in the ontogenesis
Töröková, Petra ; Brdička, Radim (advisor) ; Černý, Viktor (referee)
The main goal of this study is the comparison of sequences of the HVRII region of the mitochondrial genome in the cord blood sample and the saliva sample of the same individual, taken at average ten years from his/her birth. It is known that during ontogenesis the human genome changes. All the more the mitochondrial genome which shows a higher mutation rate, and moreover it is not taken care of it by repair mechanisms. In older individuals, there was found a distinctive amount of mitochondrial variations cumulated in different tissues in the process of the ontogenesis. This study is focused on the detection of these changes already in younger individuals. The tissue-specific variability which is created during ontogenesis might have an adverse influence on all sorts of the mtDNA based studies. The samples were taken in two regions (Teplice / Prachatice) that differ in the pollution of environment. With regard to that, the samples with discovered changes were compared from the standpoint of the region, which they had come from, with the aim to prove the influence of environment on the mutagenesis of the mitochondrial DNA. Samples were also compared from the point of view of sex. Furthermore the variability of the collection of Czech population was evaluated and the estimation of the genetic...
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Kinesiotherapy in idiopathic scoliosis focusing on the reflexlocomotion
Havlová, Zdenka ; Horká, Bohumila (advisor) ; Savková, Pavlína (referee)
Author: Zdenka Havlová Institution: Department of Rehabilitation Medicine The Faculty of Medicine in Hradec Králové Title: Kinesiotherapy in idiopathic scoliosis focusing on the reflexlocomotion Supervisor: Mgr. Bohumila Horká Pages: 89 Inserts: 5 The year of presentation: 2013 Keywords: idiopathic scoliosis, ontogenesis, axial systém, reflexlocomotion The thesis deals with the kinesiotherapy in idiopathic scoliosis taking into account the possibilities of Vojta method. It deals also with the history of this disease, incidence in the population, relation between ontogenetic development and development of the axial system. The thesis also describes the treatment options and introduces the most used method of kineziotherapy. It contains two case studies of the patients with the idiopathic scoliosis where the Vojta method was used as the main method of kinesiotherapy.
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